Name： Wang Xiu Jun
Post： Professor
Position： PI
Education： Ph.D.
Professional： Molecular Pharmacology
Departments： Department of Pharmacology
Research： Cancer Chemoprevention
TEL: 0571-88981270
E-mail: xjwang@zju.edu.cn
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Dr. Xiu Jun Wang gained her Bsc from Lanzhou University and received her Ph.D. from University of London (St. Bartholomew’s Hospital) in UK in 1996. She worked as a Research Fellow during 2000-2009 for Cancer Research UK, and joined School of Medicine, Zhejiang University in 2009.
Research interests: the aim of her research is to understand the effect of environmental toxic chemicals on tumourgenesis and to uncover novel agents for cancer chemoprevention.
Selected publications:
Wang XJ, Hayes JD, Higgins LD, Wolf CR and Dinkova-Kostova AT (2010) Activation of the nrf2 signalling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones. Chemistry & Biology 17: 75-85
Ahn Y-H, Hwang Y, Liu H, Wang XJ, Zhang Y, Stephenson KK, Boronina T, Cole RN, Dinkova-Kostova AT, Talalay P and Cole PA (2010) Electrophilic tuning of the chemoprotective natural product sulforaphane Proc. Natl. Acad. Sci. USA, 107(21): 9590-5
Wang XJ, Hayes JD, Henderson CJ and Wolf CR (2007) Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha. Proc. Natl. Acad. Sci. USA, 104(49): 19589-94
Wang XJ, Chamberlain M, Vassieva O, Henderson CJ and Wolf CR (2005) Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice. Biochem J, 388: 857-867
Ritchie KJ, Henderson CJ, Wang XJ, Vassieva O, Carrie D, Farmer PB, Gaskell M, Park K, Wolf CR (2007) Glutathione transferase pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane. Cancer Research 67 (19): 9289-57
Wright MC, Wang X-J, Pimenta M, Ribeiro V, Paine AJ and Lechner MC(1996) Glucocorticoid receptor-independent transcriptional induction of cytochrome P450 3A1 by metyrapone and its potentiation by glucocorticoid, Molecular
