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  • JI Junfeng
  • Department:Department of Stem Cell and Regenerative Medicine
  • Research centre:Research Center of Stem Cell and Regenerative Medicine
  • Course:Histology and Embryology
  • Tel:88208836
  • Research Interests:Somatic Reprogramming: The molecular mechanisms regulating human somatic cell reprogramming remain largely unknown. We are focusing on understanding the molecular regulators that influence reprogramming efficiency and quality. In particular, we are interested in understanding the role of epigenetic modifiers and metabolic regulators in modulating human somatic cell reprogramming. The study will provide insight into elucidating the molecular regulators controlling reprogramming and pave the way for improving human somatic cell reprogramming efficiency and quality for personalized regenerative medicine. Cellular Senescence/Aging: Cellular senescence plays an important role in tumorigenesis, organismal aging and embryogenesis. Accumulation of senescent cells in a variety of tissues during organismal aging contributes to the onset of age-associated diseases. However, the molecular mechanisms controlling cellular senescence remains largely unknown. In particular, we are interested in the metabolic regulation of cellular senescence, identification of biomarkers of senescent cells and clearance of senescent cells. We will exploit genomic, proteomic and metablic approaches to understanding cell senescence and aim to prolong healthy life-span of human being by targeting senescent cells during organismal aging.
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